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Wynn and Clooney first clashed in a heated argument in Las Vegas in early April after Wynn reportedly called President Barack Obama a dirty word during a group dinner.

It escalated Friday after Wynn denied making the statement about Obama, saying stars like Clooney are "mollycoddled."

"Artists, actors, people like that - they live in a very strange bubble of their own. They're mollycoddled. They're very privileged," Wynn said in an interview with Bloomberg TV's "Market Makers," according to The Hollywood Reporter.

"We're talk about successful artists like George, Barbra Streisand or any other successful artist. They live in a very small world. The people around them are very solicitous and caring for them. They have a world view that everything should be given to everybody because everything has been given to them," he continued.

However, Wynn said that despite actors' negative qualities, he and others in Las Vegas "love them anyway."

Clooney is now responding to the casino mogul's comments, People magazine reported.

"He said I live in a bubble. More of a bubble than Las Vegas? Honestly? He says I'm 'mollycoddled,' that I'm surrounded by people who coddle me. I would suggest that Mr. Wynn look to his left and right and find anyone in his sphere that says anything but 'yes' to him. Emphatically," Clooney said.

"I did not attend a private boys' school, I worked in tobacco fields and in stock rooms, and construction sites. I've been broke more of my life than I have been successful, and I understand the meaning of being an employee and how difficult it is to make ends meet," he added.

Clooney likewise refuted Wynn's denials that he made a statement against Obama.

"He now says he didn't call the president an 'a------.' That is false. He bellowed 'I voted for the a------,' and then called him the same thing several more times as the dinner came to an abrupt end," Clooney said.

The newly-engaged actor also reacted to Wynn's comments that he was "a little into tequila."

"Again there were eight people at the table, eight witnesses. I did in turn, call him the same body part, and walked out. Again he can make up whatever story he wants, but these are the facts. He said I drank 16 shots of tequila. I didn't drink one shot of tequila, not one. We were drinking but it was early and we still had two events to attend," Clooney said.